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Fruit fly genetics and publishing ethics

Playing coi with special issues: reflections from a guest editor

12/25/2024

 
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Reading time: 15 minutes
Earlier this year I wrote about my experience as a guest editor for Philosophical Transactions of the Royal Society B (Biological Sciences). That special issue was conceived of in 2022, and prior to it getting the green light, we had submitted a full proposal with 18 pages of text, half of which was text establishing the concept of the issue, and half was abstracts from authors who had already conceived of an article concept for the issue. The issue was ultimately published in March 2024, about a year and a half after its conceptualization. I already covered the conception of this issue in a previous blogpost, and how it came to be in Phil Trans B. It was overall a positive and enlightening experience.

Today I want to talk about the caveats to this praise. I took this opportunity because Philosophical Transactions of the Royal Society is the many-times-great grandparent of modern academic publishing, first established in 1665. If there was a group I could look to who would coordinate a special issue responsibly, it would be Phil Trans B. They did not disappoint. With a ~50% rejection rate of topic submissions, topics covered in Phil Trans B have to argue for why they are genuinely "special," and that is something lost in the overly broad definition of "special issue" today.
​
​The other side of this coin are special issues that are anything but special. Groups like MDPI can host thousands of special issues - each with multiple articles - collected in single journals. This is as oxymoronic as it gets. The quality control on these research topics is so lax that far too many events of unscrupulous guest editors using MDPI journals as an outlet to publish their own manuscripts can be highlighted; yes each word in that sentence links to a different problematic SI, and trust me that well is not at all dry... I just got tired of hyperlinking every word. In far too many cases, guest editors have authored the vast majority of papers in their own issue.
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Also... MDPI has been stealth-correcting articles post-hoc to make them appear as if they weren't published as part of a special issue. This behaviour was spotted by folks like Dorothy Bishop (in screenshot) who reported this perjury of the literature. Read up at: https://deevybee.blogspot.com/2024/09/now-you-see-it-now-you-dont-strange.html
In these cases, those articles are sent to external MDPI associate editors to handle, so it's not like the authors are literally rubber stamping their own work. But given how successful they are at publishing their own articles through their own SIs, they might as well have been...

And that is the crux of today's blog: the inherent conflict-of-interest (COI) that special issues present. You see, while MDPI journals offer some of the most absurd examples of how a special issue editor can abuse the system to publish their own works, the entire model of special issue publishing is rife with COIs; I can say that with confidence, as I experienced this firsthand. And I experienced such ethics concerns while guest-editing a special issue for the oldest extant academic publisher, a not-for-profit society journal with a centuries-long history and a rigorous selection process for what article collections get approved - yikes.

While I think there is a place for special issue publishing in the academic landscape, it really REALLY has to receive more oversight. And I'm not just talking about the groups like MDPI that are clearly abusing the definition of "special issue", but I'm even extending this to well-meaning and rigorous groups like Phil Trans B. The model of special issue publishing has some glaring COI problems, and as a former editor, this really should be considered and corrected moving forward. Let's dive in.
​

How can I say no to a friend?
OR: associate editors need to step in more


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PhD studentship through China Scholarship Council - deadline Dec 2nd 2024

11/13/2024

 

​Characterising the immune repertoire of a global crop pest Myzus persicae

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UoE-CSC application link:
https://www.exeter.ac.uk/study/funding/award/?id=5286
For inquiries, please email: [email protected]

Nature of funding:
This funding is a scholarship awarded to the successful Chinese student to come study at the University of Exeter, Penryn. As such, the funding is dependent on the student's success in competing for one of ~50 scholarships available to come study at the University of Exeter. The student will be supported in preparing their application by the supervisory team.


Based in:
University of Exeter, Penryn, Cornwall, UK.

Supervisory team:
Mark A. Hanson (University of Exeter, Penryn), primary
Bartek Troczka (University of Exeter, Penryn), co-primary
Chris Bass (University of Exeter, Penryn)

Project description:

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PhD studentship! Deadline Dec 11th 2024

11/13/2024

 

Evolutionary mechanisms underlying differences in the innate immune response to infection

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SWbio application link:
https://www.swbio.ac.uk/biomolecular-and-biophysical-studies/
For inquiries, please email: [email protected]

Based in:
University of Exeter, Penryn, Cornwall, UK.

Supervisory team:
Mark A. Hanson (University of Exeter, Penryn), primary
Ben Longdon (University of Exeter, Penryn), co-primary
Helen White-Cooper (Cardiff University)

Project description:

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Join the team - let's chat!

8/1/2024

 

Contact info

Please reach out ([email protected]), or through the website's "Contact" web form, and we can grab a tea/coffee in person or over Zoom.

Available projects / study systems

Updated October 24th 2024
Evolution of the innate immune system
  • Characterising the immune repertoire of global crop pest Myzus persicae aphids​
  • Evolution of innate immune signalling in a genetic model species group (Drosophilidae)
  • Effector host-pathogen interactions in an evo-immuno context
  • ​Birth of immune novelty through genomic slippage

Genetics of a non-model fly with bizarre chromosomal biology
  • ​Developing genetic tools in a non-model Drosophilid with bizarre biology
  • Fitness consequences of a "selfish X" chromosome that has been picking up mutations for ~1 million years
  • Genetics and ecology of naturally-occurring body colour variation in a woodland fly



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Projects studying immune system evolution

7/28/2024

 

It's in our genes

The lab has a core interest in studying the evolution of the immune system. We use a library of 50+ genome-sequenced fruit fly species as a model system for infection biology. By using fruit flies, we can probe questions in high-throughput, ethical, cost-effective, and genetically powerful ways. But the lab is also interested to study evolutionary questions more broadly, admittedly with a passion for insect genetics. The reason we study insects isn't arbitrary. See... vertebrates and mammals have both an adaptive and an innate immune system. However, insects have only an innate immune system. This is both a strength and a weakness for investigating immune evolution. While it means the questions we study are restricted to innate immunity, it also means we can do so with a clear signal, avoiding any statistical noise that comes from the host adaptive immune response. Insect genetics, and especially fruit fly genetics, are also immensely powerful. There are living libraries of flies where, at the click of a button, you can order tools for custom gene knockouts or overexpression in tissue-specific, timing-specific, heck... light-specific fashion. The lab is also regularly synthesizing plasmids and creating transgenic flies for our research purposes. When we have a hypothesis, we can typically test it in 3-4 different ways in a matter of weeks, generating high quality evidence. There is a reason Drosophila won the Nobel Prize in Physiology or Medicine in 2011, and again for founding the field of circadian biology in 2017: fruit flies are cool.

While the lab has projects available using fruit fly research, there is also a general interest to study immune evolution more broadly. One species we are branching out into is Myzus persicae aphids, and in the past Mark has helped in placing the phylogenetics of stalked jellyfish (staurozoa, tiny but beautiful creatures). So if you are interested in some sort of evolutionary question, particularly (but not necessarily) involving host-pathogen interactions, please get in touch.

Host-pathogen interactions in an evo-immunology context

Suitable for Masters, PhD, or Postdoctoral researchers
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Immune genes evolve faster than almost any other gene in the genome. My work on antimicrobial peptides revealed how these host defence genes contribute to killing pathogens. What I found defied assumptions about immune defences that had held for decades, and blew the field of host peptide-pathogen evolutionary interactions wide open. These are still early days, but my work in the model fruit fly Drosophila melanogaster suggested that single peptides were immensely important for defence against specific microbes. What was striking was how you could delete entire groups of other defence peptides with no effect on survival outcome. In Hanson et al. (2023; Science, pdf here), I took this a step further, describing why these highly specific host effector-pathogen interactions exist: they're a product of millions of years of host evolution to ecological microbiome compositions. So these things I was seeing in the lab weren't just artefacts of our infection system, they reflected something ancient and meaningful.

To date, my own work and the broader field of Drosophila immunity has described numerous highly-specific host peptide-microbe interactions. Yet the causative mechanisms remain poorly understood. It's also unclear how far beyond D. melanogaster one can trust a host-pathogen interaction to play by the same rules. And if different species do play by different rules, what are those rules? Are there signals we can look for to tell us when something is expected to behave the same or different from our classic model organism that we know so well? As the first line of defence against infection, and the core effectors that actually do the killing, antimicrobial peptides and other effector mechanisms (e.g. melanisation) are key arenas of host-pathogen evolution. There are so many observations to follow up on, and even genetic tools in the lab just waiting for a motivated student to use. Please reach out if you'd like to reveal some of the core principles of host-pathogen interactions using a powerful genetic model system.

Characterising the immune repertoire of a global crop pest Myzus persicae aphids

Suitable for Masters, PhD, or Postdoctoral researchers

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Developing genetic tools in a non-model fly with a bizarre selfish chromosome

7/28/2024

 
The lab has a number of projects related to Drosophila testacea genetics. This species has a fascinating and bizarre selfish chromosome, segregating genetic alleles, and a potential for truly impactful evolutionary biology tools at a fundamental level - and I'm not just saying that.​ These projects are suited for any level of investigation, from undergraduate term projects to enabling postdoctoral research fellowship programmes. If any of the projects below pique your interest, please reach out! I am passionate to get this study system running at full speed, and interested researchers are more than welcome on board.

Using CRISPR to develop novel genetic tools in Drosophila testacea

Suitable for Masters, PhD, or Postdoctoral researchers

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PhD studentship available (deadline July 29th 2024)

7/18/2024

 
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A short but sweet post: join us!

I have a funded PhD studentship opportunity to for 3.5 years to characterise aphid immune evolution. Details can be found at the link below:
www.exeter.ac.uk/study/funding/award/?id=5191

The project is co-supervised by myelf (lead supervisor), Bartek Troczka, and Chris Bass.

Feel free to drop me an email at [email protected] for more information. You can also use the Contact form on the website here.

Cheers,
​Mark

We need a new "Special Issue" lexicon

3/24/2024

 
Reading time: 13 minutes
TLDR: "Watercooler" and "Frankenstein" Special Issues are very different things. We should really be distinguishing them from each other. It's publishers that profit off of free guest editor work that want us to view all things called "Special Issues" as similar products. They aren't, and we need terms that define a spectrum for what goes into editing a "Special Issue."
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Figure: Special Issue (red) and Regular Issue (blue) articles by publisher from The strain on scientific publishing.
Author note: I refer to "groups like MDPI" in this blog. While MDPI is a poster child for Special Issue publishing, they are by no means alone. Those comments apply to all groups  engaging in such practices.
This blog is the first in a series of reflections on special issue publishing
So you may have read a preprint recently: "The strain on scientific publishing." I found the topic fascinating; heck, I was lead author. In that preprint, we highlighted two mechanisms of publisher growth that generates strain, one of which was the use of "Special Issues" (emphasis on the air quotes). Some publishers have adopted Special Issues as an outlet for publishing guest-edited articles en masse. Now, our preprint took off across the globe, being covered in English, Spanish, Arabic, and Swahili... just to name a few. Somewhat as a result, we've even been attacked by Frontiers Media for somehow being "anti-special issue," which is the topic of today's post: am I anti-special issue? I don't think so. After all, I just finished editing one.
But I do have to say... there are some things you realise when you're on the inside looking out. Editing this special issue only convinced me that the conversation around modern day "Special Issues" needs a serious update. We don't need to stop funding the publishing of Special Issue articles (SNSF, 2023), we just need to "make Special Issues special once again" (Priem, 2007).

So what do I mean? Well...
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Hanson, Westlake, & Schrankel (2024)

What is a journal?
OR: The rules of publishing changed

Before I get to Special Issues, I think it's important to discuss where they're published. Even more important to understanding their value, I think it's also worth talking about "when."

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MDPI mega-journal delisted by Clarivate / Web of Science

3/25/2023

23 Comments

 
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Reading time: 8-10 minutes
This blog has been critical of MDPI in the past. That came about honestly: in 2021 I looked at how inflated a journal's Clarivate Journal Impact Factor was relative to a metric that has built-in rank normalizers, the SciMago Journal rank. In that analysis, MDPI was far and away the most severe in terms of Impact Factor Inflation, having significantly different citation behaviour compared to all not-for-profit publishers, but also compared to for-profit Open Access publishers like BioMed Central (BMC) and even Frontiers Media ("Frontiers in ____").
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Impact Factor Inflation is a metric of anomolous citation behaviour. It reveals publishers whose Clarivate Journal Impact Factors (IF) are much higher than expected if one normalizes for the network of journals citing that publisher (using Scimago Journal Rank = SJR). The SJR formula does not reward self-citation, or receiving many citations from only a small pool of journals. Thus when a journal has a very high Impact Factor compared to SJR (suggested litmus test = 4x higher), it reveals when that Impact Factor has been inflated by self-citation, or small self-citing circles of authors/journals.

​I followed that analysis with a simple poll asking Twitter users what their opinions were of various publishers. I repeated that poll in 2023 on both Twitter and Mastodon getting basically the same result (if anything, more settled into camps): nearly everyone labelled MDPI a somewhat or outright "predatory" publisher.
Poll from 2021 asking users "What is your opinion of publisher ____"? on Twitter. Sample sizes per publisher response given in bars.
Poll from 2023 asking users "What is your opinion of publisher ____"? on Twitter and Mastodon. Sample sizes per publisher response given in bars.
Opinions polls of academic publishers asking "What do you think of publisher ___?" conducted in 2021 and 2023 on Twitter and/or Mastodon.
I was far from the first to highlight MDPI's poor reputation. Dan Brockington held a questionnaire series asking affiliates of MDPI (authors, reviewers, editors) on their opinion of the publisher in ~2020. I particularly love one of his simple summaries of the heart of the issue regarding MDPI's publishing behaviour: "​Haste may not necessarily lead to mistakes, but it makes them more likely."
"​Haste may not necessarily lead to mistakes, but it makes them more likely."

- Dan Brockington
Around the same time, Paolo Crosetto wrote a fantastic piece on MDPI's anomolous growth of Special Issues. Year-after-year growth of Special Issues exploded between 2020 and 2021, going from 6,756 in 2020 to 39,587 in 2021. The journal Sustainability has been publishing ~10 special issues per day: and keep in mind a special issue is often comprised of ~10 articles. As Crosetto put it: "If each special issue plans to host six to 10 papers, this is 60 to 100 papers per day. At some point, you are bound to touch a limit – there possibly aren’t that many papers around... That’s not to talk about quality, because even if you manage to attract 60 papers a day, how good can they be?”
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Analysis of total special issues hosted by MDPI journals with Impact Factors in 2021 from Paolo Crosetto's fantastic piece on the topic.

​At some point, you are bound to touch a limit – there possibly aren’t that many papers around.
​
- Paolo Crosetto

​This really resonated with me, particularly as someone who is currently hosting a special issue with a different (society journal) publisher. Special Issues are supposed to be special; it's easy to forget that sometimes, but it's actually very important!

Not-so-special issues


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23 Comments

A year later: what is a predatory publisher anyways?

2/9/2023

 
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Reading time: 10-12 minutes
In this article:
  • "Predatory publishing" is an overly-vague term
  • Poll 2023: What is a predatory publisher anyways?
  • Moving past the word "predatory"
    • Vampire press (similar to "vanity press")
    • Rent-seeker / Rent-extractor
    • Scam
​Edit Feb 15th 2023: added term "vanity press" to Vampire press section to highlight similarities and distinctions in use between the two terms.
Edit Mar 25th 2023: moved Twitter vs. Mastodon tangent to "p.s." section

A year ago I wrote a blogpost called "What is a predatory publisher anyways?" In that post I looked at the origin of the term in 2012, and what it meant at its inception. I held a Twitter poll, gathering ~175 respondents from across the spectrum that asked people's opinions on whether various publishing groups were "predatory."

​SPOILERS: I just redid the poll in Jan 2023 on both Twitter and Mastodon.


The aim of that poll was not only to get a sense of publisher reputations, but to look at what are the behaviours of publishers that people associate with "predatory publishing." What did I learn in 2021? Well... not exactly what I expected (fun!).
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NOVEMBER 2021 RESULTS asking the question: "What is your opinion of _____?" with the four options listed.
"Predatory publishing" is an overly-vague term

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